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PloS one [16 Sep , 8 9 :e]. Type: Research Support, Non-U. Abstract In Portugal, pneumococcal conjugate vaccines have been administered to children outside of the national immunization plan since We determined the serotype and antimicrobial susceptibility of isolates responsible for adult invasive pneumococcal infections IPD between and and compared the results with previously published data from to Serotypes 3 Serotypes 1 and 5 declined significantly while serotype 34, not included in any vaccine, increased.
Taken together, the serotypes included in the valent conjugate vaccine PCV13 peaked among adult IPD isolates in The decline in the serotypes included in the valent polysaccharide vaccine since was also significant but much more modest with Since the changes in serotypes causing IPD in adults coincided with the valent and PCV13 introduction in children, it is unlikely that vaccination triggered these changes although it may have accelerated them.
The proportion of IPD caused by serotypes included in the 7-valent conjugate vaccine remained stable Both penicillin non-susceptibility and erythromycin resistance increased in the study period, with serotypes 14 and 19A accounting for the majority of resistant isolates.
Read Article at publisher's site. How does Europe PMC derive its citations network? Protein Interactions. Protein Families.